Dynamic DNA structures and the formation of memory | Science & Technology

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An international collaborative research team, including scientists from UQ’s Queensland Brain Institute (QBI), has discovered a novel mechanism underlying memory involving rapid changes in a specific DNA structure.

The team found that G-quadraplex DNA (G4-DNA) accumulates in neurons and dynamically controls the activation and repression of genes underlying long-term memory formation.

In addition, using advanced CRISPR-based gene editing technology, the team revealed the causal mechanism underlying the regulation of G4-DNA in the brain, which involves site-directed deposition of the DNA helicase, DHX36.

The new study, published in the Journal of Neuroscience, provides the first evidence that G4-DNA is present in neurons and functionally involved in the expression of different memory states.

The study, led by Dr Paul Marshall at the Australian National University and QBI and a team of collaborators from Linköping University, Weizmann Institute of Science, and the University of California Irvine, highlights the role that dynamic DNA structures play in memory consolidation.

DNA flexibility

For decades, many scientists considered the topic of DNA to be solved. DNA is widely…

Source www.sciencedaily.com

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