How Some People’s Body Resists Getting COVID | Technology & Science

Why Some People Haven’t Caught COVID despite Being Exposed.

When scientists exposed people to the virus that causes COVID, only a subset got sick. Studying them could offer clues to immunity.

Not everyone who is exposed to SARS-CoV-2, the virus that causes COVID, gets the disease. New research published in June in Nature may partly explain why: In a 2021 experiment called a challenge study, researchers attempted to infect 16 unvaccinated volunteers with a low dose of the original strain of SARS-CoV-2. Participants who quickly squelched the virus activated a fast-acting innate immune response in their nose.

In the study, the team first assessed the participants’ baseline immune function and then spritzed an infectious solution into their nose. For four weeks afterward, the researchers collected nasal swabs and blood samples from the subjects for single-cell DNA sequencing analysis. This offered the scientists “an unprecedented view of…


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